WHAT IS THE MPC?
- In large bacterial populations, spontaneous genetic mutations can occur; this phenomenon cannot be prevented
- These mutations occur at a rate of around 1 in 10 million (107) bacteria3; hence in clinical infections where this size of infection is present first step mutants will naturally be present7
- These mutant cells may be less susceptible to the antibiotic being used. The result can be that the resistant strain is selected for and will multiply1,2